It depends on what you know and/or are willing to learn due to the benefits.
It is certainly true that you can use "just windows application", but MFC can be easier to program because it provides many of the details that would otherwise need more of our time. It helps to know how to write a Windows program without MFC, but we must start somewhere and you can start learning MFC first, then learn about Windows, then learn more about MFC. Or something like that.
I am not sure I understand what you mean by "interface". Do you mean User Interface (UI) If not, then you probably should clarify what you mean.
There are some MFC General Samples that might help. You can use them to become familiar with MFC and what can be done using MFC.